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All About Bleeding

Bleeding Risk of Warfarin Therapy

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Uncontrolled bleeding is the most serious and common side effect of warfarin therapy. The majority of bleeding incidents are minor and include nose bleeds, bruising and bleeding after a minor injury.5

Major hemorrhages from warfarin-induced bleeding, are reported at a rate of 1–12% per patient per year.6-9

  • Intracranial hemorrhage is increased 7- to 10-fold in patients receiving warfarin, to a rate of nearly 1% per patient per year, with an estimated 60% mortality rate.6-7
  • Hemorrhage caused by excessive anticoagulation has been shown to contribute independently to increased morbidity and mortality and is an independent predictor of 60-day mortality. Fatal or life-threatening bleeding risk is estimated to range between 1% and 3%.6, 9-10

Bleeding risk is influenced by the intensity of anticoagulation therapy and age. The risk of hemorrhage in patients receiving oral anticoagulation therapy is directly related to the degree of prolongation of the INR value. As the INR rises above 5.0, the risk of bleeding increases exponentially.11-13

Last Updated: 7/11/2013 4:25 PM
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