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All About Bleeding

Platelet Dysfunction

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The Coagulation Cascade

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Platelet concentrates
Platelet concentrates are used in a range of situations:27

  • Preventing bleeding in asymptomatic, severe thrombocytopenia
  • Treating bleeding in patients with less severe thrombocytopenia
  • Treating bleeding in patients with platelet dysfunction due to antiplatelet drugs but with normal platelet count
  • In patients receiving massive transfusion that dilutes platelets to low levels
  • Before invasive surgery, as appropriate.

Treatments for VWD
Platelet dysfunction has many causes. In the most common condition, von Willebrand disease (VWD), the two treatments of choice are desmopressin and von Willebrand factor (VWF) concentrate:23

  • Desmopressin is an analog of vasopressin, originally intended to treat diabetes. It stimulates release of VWF from endothelial sites. Its side effect profile, low cost and non-risk of transmitting blood-borne viruses have made it a widely used agent to treat VWD.23
  • Virus-inactivated VWF concentrate is considered the treatment of choice in patients unresponsive to desmopressin.23
Before VWF was available, cryoprecipitate was commonly used if desmopressin treatment was not successful, and is still used in countries where VWF is unavailable. Where possible, cryoprecipitate should be prepared from virus-inactivated plasma.23

Not all products are available in every country. To learn what products are available in your country, visit your CSL Behring country site.

Last Updated: 11/5/2012 12:01 AM
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