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All About Bleeding

Fibrinogen (Factor I) Deficiencies

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Signs & Symptoms

Bleeding manifestations in afibrinogenemia can range from mild to severe and can include:6, 7

  • Nosebleed and bleeding of the gums
  • Bleeding into joints (hemarthrosis) and accumulation of blood in muscles (hematoma)
  • Gastrointestinal bleeding
  • Abnormally heavy bleeding during menstruation and bleeding associated with childbirth
  • Bleeding after trauma or surgery
  • Spontaneous rupture of the spleen and bleeding inside the skull (rare)
  • Umbilical cord bleeding
Bleeding episodes in patients with hypofibrinogenemia are usually mild, with no obvious spontaneous bleeding. However, bleeding may occur following trauma or surgery (perioperative bleeding). Both afibrinogenemia and hypofibrinogenemia can be associated with thrombosis and recurrent spontaneous abortion.7

Last Updated: 11/3/2012 11:06 PM
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