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All About Bleeding
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Bleeding Disorders

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About Bleeding Disorders

Globally, more than 1% of the world's population is affected by bleeding disorders such as hemophilia A, hemophilia B (Christmas disease) or von Willebrand disease (VWD). Bleeding problems can range from mild to severe. Symptoms typically include prolonged bleeding from minor wounds and bruising easily. Such bleeding varies in severity and duration and can cause symptoms ranging from nosebleeds, bleeding gums, easy bruising, heavy menstruation (menorrhagia), to bleeding into soft tissues (muscle bleeding) and joints causing arthritic-type symptoms1. In severe cases, treatment of spontaneous bleeding involves prompt and proper use of clotting factor concentrates. Prophylactic treatment is possible in many cases.

Bleeding disorders are broadly classified as inherited or acquired:

  • Inherited (congenital) bleeding disorders are caused by defects or damage in a developing fetus. They can be inherited via genetic abnormalities or develop as a consequence of problems in the intrauterine environment such as infections. 1
  • Acquired bleeding disorders develop or spontaneously occur during the life of the individual.2
Examples of inherited bleeding disorders Examples of acquired bleeding disorders

Major causes of acquired bleeding disorders include warfarin-induced bleeding, massive blood loss (e.g. perioperative bleeding or bleeding in critically ill patients) and liver disease.2

  1. Asselta R, Duga S, Tenchini ML. The molecular basis of quantitative fibrinogen disorders. J Thromb Haemost 2006;4(10):2115-29.
  2. Peyvandi F, Palla R. Fibrinogen concentrates. Clin Adv Hematol Oncol 2009;7(12):788-90.

Last Updated: 12/30/2014 5:04 PM
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