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All About Bleeding

Hemophilia A

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26 May 2016 - The First and Only Recombinant Factor VIII Single Chain Therapy for Hemophilia A

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Hemophilia A is the most common type of hemophilia, comprising about 80% of hemophilia cases. In two-thirds of cases, hemophilia A is an inherited bleeding disorder and the disposition is known (positive family history). The other one-third of cases is due to new mutations, and thus the family history will be negative.

Symptoms of Hemophilia A

People born with hemophilia A are usually males, because the gene is located on the X-chromosome. Females have two X-chromosomes, one of which is usually a healthy X-chromosome, which compensates for a potentially defective Factor VIII (FVIII) gene on the other (however, this makes them carriers of hemophilia A). This compensation does not work in males, who have only one X-chromosome and a Y-chromosome.

The symptoms of hemophilia A may vary from occasional to frequent spontaneous bleedings. Acquired hemophilia A occurs when healthy people form auto-antibodies against FVIII. Triggers for the development of acquired hemophilia A may include pregnancy or other medical conditions.

The most common hemophilia A symptoms are:
  • Hematomas (for example, an infant born with hemophilia A may bruise simply from being lifted)
  • Bleeding in the mouth from a cut or bite or from losing a tooth
  • Hemarthrosis (tightness, swelling, warmth and/or pain in the joints)
  • Bleeding into soft tissues
  • Heavy bleeding from a minor cut
  • Cuts that bleed again after they have already stopped for a short time
  • Gastrointestinal, genitourinary, or intracranial bleeding

For more information about hemophilia A treatment options, please visit the following resources:

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Last Updated: 4/17/2017 5:06 PM
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