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All About Bleeding

Factor XIII Deficiency

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Signs and Symptoms

A wide range of symptoms are associated with factor XIII deficiency. Bleeding is often delayed, because clots are initially successful in stopping bleeding. However, they are not stable; after a few days, the clot dissolves, and bleeding starts again at the original site of injury.

Types of bleeding that may suggest factor XIII deficiency include:18

  • Central nervous system bleeding, which recurs in approximately 30% of patients with inherited factor XIII deficiency. Bleeding into the brain (intracranial hemorrhage) can be the first symptom in adults, without any preceding trauma. Symptoms such as headaches, seizures, vomiting, or disturbances in eyesight may precede a CNS bleed
  • Recurrent spontaneous miscarriage
  • Bleeding from the umbilical cord during the first 2–3 weeks of life
  • Persistent, delayed or recurrent bleeding following surgery
  • Bleeding into the soft tissues or joints
  • Bruising
  • Poor wound healing






Last Updated: 12/30/2014 11:32 AM
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