Replacement of factor XIII is used to treat bleeding or prevent bleeding during or immediately after surgery (perioperative bleeding ). It is also used to prevent recurrent bleeding. The success of therapy must always be monitored by assessing factor XIII levels.
Factor XIII concentrates are used for the treatment of factor XIII deficiency.29
Factor XIII replacement therapy to prevent bleeding is used mainly in patients with inherited factor XIII deficiency who are at risk of intracranial bleeding and/or recurrent miscarriages. To reduce the risk of severe, life-threatening bleeds, it has also been recommended that patients with inherited factor XIII deficiency and clinically significant bleeding should start receiving factor XIII replacement therapy in childhood.30 Levels of factor XIII above 3–5% of normal are usually enough to prevent spontaneous bleeding.31
CSL Behring products for Factor XIII deficiency treatment
CSL Behring factor XIII products include:
Corifact.com (United States)
Not all products are available in every country. To learn what products are available in your country, visit your CSL Behring country site.
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