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All About Bleeding

Bleeding Disorders

Understanding Coagulation

Learn more about the physiological process of blood coagulation.

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CSL Behring & Therapies

Coagulation therapy is the foundation of CSL Behring’s broad range of therapies.

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About Bleeding Disorders

Bleeding disorders can affect primary (e.g. platelets, von Willebrand factor) or secondary hemostasis (e.g. coagulation factors). Secondary hemostasis is usually called coagulation, and related disorders are referred to as coagulopathies. Excessive and prolonged bleeding can occur if a particular component of coagulation is deficient or dysfunctional. Such bleeding varies in severity and duration and can cause symptoms ranging from epistaxis, gingival bleeding, hematomas, menorrhagia, to muscle bleeding and hemarthrosis causing arthritic-type symptoms.1

Bleeding disorders are broadly classified as congenital or acquired:
  • Congenital bleeding disorders are present at birth. They can be inherited or appear de novo by a genetic mutation. 2
  • Acquired bleeding disorders develop or spontaneously occur during the life of the individual.3
Examples of inherited bleeding disorders Examples of acquired bleeding disorders

Major causes of acquired bleeding disorders include bleeding caused by treatment with vitamin K antagonists such as warfarin, perioperative bleeding or bleeding in critically ill patients caused by massive blood loss and hemorrhagic diathesis caused by liver disease.3

  1. Ma A. Evaluation of the bleeding patient. In: Key N, Makris M, O'Shaughnessy D, Lillicrap D, editors. Practical Hemostasis and Thrombosis. 2nd ed: Wiley-Blackwell, 2009:48–60.
  2. Asselta R, Duga S, Tenchini ML. The molecular basis of quantitative fibrinogen disorders. J Thromb Haemost 2006;4(10):2115-29.
  3. Peyvandi F, Palla R. Fibrinogen concentrates. Clin Adv Hematol Oncol 2009;7(12):788-90.

Last Updated: 6/25/2013 10:59 AM
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